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Inhibiting DNA methylation alters olfactory extinction but not acquisition learning in Apis cerana and Apis mellifera
Gong, Zhiwen; Wang, Chao; Nieh, James C.; Tan, Ken
2016
Source PublicationJOURNAL OF INSECT PHYSIOLOGY
Volume90Issue:xPages:43-48
AbstractDNA methylation plays a key role in invertebrate acquisition and extinction memory. Honey bees have excellent olfactory learning, but the role of DNA methylation in memory formation has, to date, only been studied in Apis mellifera. We inhibited DNA methylation by inhibiting DNA methyltransferase (DNMT) with zebularine (zeb) and studied the resulting effects upon olfactory acquisition and extinction memory in two honey bee species, Apis cerana and A. mellifera. We used the proboscis extension reflex (PER) assay to measure memory. We provide the first demonstration that DNA methylation is also important in the olfactory extinction learning of A. cerana. DNMT did not reduce acquisition learning in either species. However, zeb bidirectionally and differentially altered extinction learning in both species. In particular, zeb provided 1 h before acquisition learning improved extinction memory retention in A. mellifera, but reduced extinction memory retention in A. cerana. The reasons for these differences are unclear, but provide a basis for future studies to explore species-specific differences in the effects of methylation on memory formation.
KeywordApis Cerana Apis Mellifera Dna Methylation Acquisition Learning And Memory Extinction Learning And Memory
Document Type期刊论文
Identifierhttp://ir.xtbg.org.cn/handle/353005/10001
Collection2012年后新成立研究组
Recommended Citation
GB/T 7714
Gong, Zhiwen,Wang, Chao,Nieh, James C.,et al. Inhibiting DNA methylation alters olfactory extinction but not acquisition learning in Apis cerana and Apis mellifera[J]. JOURNAL OF INSECT PHYSIOLOGY,2016,90(x):43-48.
APA Gong, Zhiwen,Wang, Chao,Nieh, James C.,&Tan, Ken.(2016).Inhibiting DNA methylation alters olfactory extinction but not acquisition learning in Apis cerana and Apis mellifera.JOURNAL OF INSECT PHYSIOLOGY,90(x),43-48.
MLA Gong, Zhiwen,et al."Inhibiting DNA methylation alters olfactory extinction but not acquisition learning in Apis cerana and Apis mellifera".JOURNAL OF INSECT PHYSIOLOGY 90.x(2016):43-48.
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