Advanced   Register
XTBG OpenIR  > 能源植物分子育种研究组  > 期刊论文

title: Searching the Evolutionary Origin of Epithelial Mucus Protein Components-Mucins and FCGBP
author: Lang, Tiange;  Klasson, Sofia;  Larsson, Erik;  et al
Issued Date: 2016
Abstract: The gel-forming mucins are large glycosylated proteins that are essential components of the mucus layers covering epithelial cells. Using novel methods of identifying mucins based on profile hidden Markov models, we have found a large number of such proteins in Metazoa, aiding in their classification and allowing evolutionary studies. Most vertebrates have 5-6 gel-forming mucin genes and the genomic arrangement of these genes is well conserved throughout vertebrates. An exception is the frog Xenopus tropicalis with an expanded repertoire of at least 26 mucins of this type. Furthermore, we found that the ovomucin protein, originally identified in chicken, is characteristic of reptiles, birds, and amphibians. Muc6 is absent in teleost fish, but we now show that it is present in animals such as ghost sharks, demonstrating an early origin in vertebrate evolution. Public RNA-Seq data were analyzed with respect tomucins in zebrafish, frog, and chicken, thus allowing comparison in regard of tissue and developmental specificity. Analyses of invertebrate proteins reveal that gel-forming-mucin type of proteins is widely distributed also in this group. Their presence in Cnidaria, Porifera, and in Ctenophora (comb jellies) shows that these proteins were present early in metazoan evolution. Finally, we examined the evolution of the FCGBP protein, abundant in mucus and related to gel-forming mucins in terms of structure and localization. We demonstrate that FCGBP, ubiquitous in vertebrates, has a conserved N-terminal domain. Interestingly, this domain is also present as an N-terminal sequence in a number of bacterial proteins.
Source: MOLECULAR BIOLOGY AND EVOLUTION
Appears in Collections:能源植物分子育种研究组_期刊论文

Files in This Item:

File SizeFormat
Searching the Evolutionary Origin of Epithelial Mucus Protein Components-Mucins and FCGBP .pdf325KbAdobe PDFView  Download


全文许可: Creative Commons 署名-非商业性使用-相同方式共享 3.0

Recommended Citation:
Lang, Tiange,Klasson, Sofia,Larsson, Erik,et al. Searching The Evolutionary Origin Of Epithelial Mucus Protein Components-mucins And Fcgbp[J]. Molecular Biology And Evolution,2016,33(8):1921-1936.

SCI Citaion Data:
Service
 Recommend this item
 Sava as my favorate item
 Show this item's statistics
 Export Endnote File
Google Scholar
 Similar articles in Google Scholar
 [Lang, Tiange]'s Articles
 [Klasson, Sofia]'s Articles
 [Larsson, Erik]'s Articles
CSDL cross search
 Similar articles in CSDL Cross Search
 [Lang, Tiange]‘s Articles
 [Klasson, Sofia]‘s Articles
 [Larsson, Erik]‘s Articles
Scirus search
 Similar articles in Scirus
Related Copyright Policies
Null
Social Bookmarking
  Add to CiteULike  Add to Connotea  Add to Del.icio.us  Add to Digg  Add to Reddit 
所有评论 (0)
暂无评论
 
评注功能仅针对注册用户开放,请您登录
您对该条目有什么异议,请填写以下表单,管理员会尽快联系您。
内 容:
Email:  *
单位:
验证码:   刷新
您在IR的使用过程中有什么好的想法或者建议可以反馈给我们。
标 题:
 *
内 容:
Email:  *
验证码:   刷新

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Powered by CSpace