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title: Neuroprotective and Anti-Inflammatory Effects of Diphenylheptanes from the Fruits of Amomum tsaoko, a Chinese Spice
author: Zhang, Tian-Tian;  Lu, Chuan-Li;  Jiang, Jian-Guo
Issued Date: 2016
Abstract: Two novel diphenylheptanes, 2,3- dihydro-2 - (4' - hydroxy-phenylethyl) - 6 - [(3aEuro(3),4aEuro(3) - dihydroxy-5" - methoxy) phenyl] -4 - pyrone (CG-A) and 4 - dihydro-2 - (4' - hydroxy-phenylmethyl) -6 - [(3",4aEuro(3) - dihydroxy-5aEuro(3) - methoxyphenyl) methylene]-pyran-3, 5 - dione (CG-B), were isolated from the dried fruits of Amomum tsaoko, a commercially important spice. This study was designed to investigate their protective effects against H2O2-induced nerve injury, using PC-12 cells to determine the cell cytotoxicity and cell viability. The inhibitory effect on (nitric oxide) NO production was also determined in (lipopolysaccharide) LPS-stimulated macrophage RAW 264.7 cells. The results showed that CG-A and CG-B displayed significant neuroprotective effect and exhibited anti-inflammatory activity in a dose-dependent manner. These findings suggest that CG-A and CG-B are very important nutritional ingredients responsible for the neuroprotective and anti-inflammatory health benefits of A. tsaoko.
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Recommended Citation:
Zhang, Tian-Tian,Lu, Chuan-Li,Jiang, Jian-Guo. Neuroprotective And Anti-inflammatory Effects Of Diphenylheptanes From The Fruits Of Amomum Tsaoko, A Chinese Spice[J]. Plant Foods For Human Nutrition,2016,71(4):450-453.

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