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Chlorotheolides A and B, Spiroketals Generated via Diets-Alder Reactions in the Endophytic Fungus Pestalotiopsis theae
Liu, L; Han, Y; Xiao, JH; Li, L; Guo, LD; Jiang, XJ; Kong, LY; Che, YS
2016
Source PublicationJOURNAL OF NATURAL PRODUCTS
ISSN0163-3864
Volume79Issue:10Pages:2616-2623
AbstractChlorotheolides A (1) and B (2), two new spiroketals possessing the unique [4,7]methanochromene and dispirotrione skeletons, respectively, and their putative biosynthetic precursors, 1-undecen-2,3-dicarboxylic acid (3) and maldoxin (4), were isolated from the solid substrate fermentation of the plant endophytic fungus Pestalotiopsis theae (N635). Their structures were elucidated based on NMR spectroscopic data and electronic circular dichroism calculations. Biogenetically, compounds 1 and 2 could be generated from the co-isolated 3 and 4 via Diels Alder reactions. Chlorotheolide (2) showed an antiproliferative effect against the human tumor cell line HeLa and induced an autophagic process in the cells.
Keyword42 Cycloaddition Organic-synthesis Natural-products Diels-alderase Chloropupukeananin Biosynthesis Chemistry Maldoxin Biology Fici
Language英语
Document Type期刊论文
Identifierhttp://ir.xtbg.org.cn/handle/353005/10212
Collection文献共享
Recommended Citation
GB/T 7714
Liu, L,Han, Y,Xiao, JH,et al. Chlorotheolides A and B, Spiroketals Generated via Diets-Alder Reactions in the Endophytic Fungus Pestalotiopsis theae[J]. JOURNAL OF NATURAL PRODUCTS,2016,79(10):2616-2623.
APA Liu, L.,Han, Y.,Xiao, JH.,Li, L.,Guo, LD.,...&Che, YS.(2016).Chlorotheolides A and B, Spiroketals Generated via Diets-Alder Reactions in the Endophytic Fungus Pestalotiopsis theae.JOURNAL OF NATURAL PRODUCTS,79(10),2616-2623.
MLA Liu, L,et al."Chlorotheolides A and B, Spiroketals Generated via Diets-Alder Reactions in the Endophytic Fungus Pestalotiopsis theae".JOURNAL OF NATURAL PRODUCTS 79.10(2016):2616-2623.
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