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Counting on natural products for drug design
Rodrigues, T; Reker, D; Schneider, P; Schneider, G
2016
Source PublicationNATURE CHEMISTRY
ISSN1755-4330
Volume8Issue:6Pages:531-541
AbstractNatural products and their molecular frameworks have a long tradition as valuable starting points for medicinal chemistry and drug discovery. Recently, there has been a revitalization of interest in the inclusion of these chemotypes in compound collections for screening and achieving selective target modulation. Here we discuss natural-product-inspired drug discovery with a focus on recent advances in the design of synthetically tractable small molecules that mimic nature's chemistry. We highlight the potential of innovative computational tools in processing structurally complex natural products to predict their macromolecular targets and attempt to forecast the role that natural-product-derived fragments and fragment-like natural products will play in next-generation drug discovery.
KeywordCatalytic Enantioselective Synthesis Inspired Compound Collection Diversity-oriented Synthesis Relevant Chemical Space Target Prediction Macromolecular Targets Combinatorial Library Network Pharmacology Medicinal Chemistry Ligand Discovery
Indexed ByWOS:000376529000007
Language英语
Document Type期刊论文
Identifierhttp://ir.xtbg.org.cn/handle/353005/10217
Collection文献共享
Recommended Citation
GB/T 7714
Rodrigues, T,Reker, D,Schneider, P,et al. Counting on natural products for drug design[J]. NATURE CHEMISTRY,2016,8(6):531-541.
APA Rodrigues, T,Reker, D,Schneider, P,&Schneider, G.(2016).Counting on natural products for drug design.NATURE CHEMISTRY,8(6),531-541.
MLA Rodrigues, T,et al."Counting on natural products for drug design".NATURE CHEMISTRY 8.6(2016):531-541.
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