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Feeling Nature's PAINS: Natural Products, Natural Product Drugs, and Pan Assay Interference Compounds (PAINS)
Baell, JB
2016
Source PublicationJOURNAL OF NATURAL PRODUCTS
ISSN0163-3864
Volume79Issue:3Pages:616-628
AbstractWe have previously reported on classes of compounds that can interfere with bioassays via a number of different mechanisms and termed such compounds Pan Assay INterference compoundS, or PAINS. These compounds were defined on the basis of high-throughput data derived from vendor-supplied synthetics. The question therefore arises whether the concept of PAINS is relevant to compounds of natural origin. Here, it is shown that this is indeed the case, but that the context of the biological readout is an important factor that must be brought into consideration.
KeywordPotassium Channel Kv1.3 Clinical-trials Crystal-structure Toxicological Evaluation Chemical-properties Reactive Compounds Molecular-basis Vitamin-k Discovery Inhibitors
URL查看原文
Language英语
Document Type期刊论文
Identifierhttp://ir.xtbg.org.cn/handle/353005/10220
Collection文献共享
Recommended Citation
GB/T 7714
Baell, JB. Feeling Nature's PAINS: Natural Products, Natural Product Drugs, and Pan Assay Interference Compounds (PAINS)[J]. JOURNAL OF NATURAL PRODUCTS,2016,79(3):616-628.
APA Baell, JB.(2016).Feeling Nature's PAINS: Natural Products, Natural Product Drugs, and Pan Assay Interference Compounds (PAINS).JOURNAL OF NATURAL PRODUCTS,79(3),616-628.
MLA Baell, JB."Feeling Nature's PAINS: Natural Products, Natural Product Drugs, and Pan Assay Interference Compounds (PAINS)".JOURNAL OF NATURAL PRODUCTS 79.3(2016):616-628.
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