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Signal integration in the endoplasmic reticulum unfolded protein response
Ron, D; Walter, P
2007
Source PublicationNATURE REVIEWS MOLECULAR CELL BIOLOGY
ISSN1471-0072
Volume8Issue:7Pages:519-529
AbstractThe endoplasmic reticulum ( ER) responds to the accumulation of unfolded proteins in its lumen (ER stress) by activating intracellular signal transduction pathways-cumulatively called the unfolded protein response (UPR). Together, at least three mechanistically distinct arms of the UPR regulate the expression of numerous genes that function within the secretory pathway but also affect broad aspects of cell fate and the metabolism of proteins, amino acids and lipids. The arms of the UPR are integrated to provide a response that remodels the secretory apparatus and aligns cellular physiology to the demands imposed by ER stress.
KeywordMessenger-rna Translation Plasma-cell Differentiation Induced Gene-expression Er Stress Transcription Factor Transmembrane Protein Glucose-homeostasis Hypoxic Stress Proapoptotic Bax Mammalian-cells
Indexed ByWOS:000247463500012
Language英语
Document Type期刊论文
Identifierhttp://ir.xtbg.org.cn/handle/353005/10250
Collection文献共享
Recommended Citation
GB/T 7714
Ron, D,Walter, P. Signal integration in the endoplasmic reticulum unfolded protein response[J]. NATURE REVIEWS MOLECULAR CELL BIOLOGY,2007,8(7):519-529.
APA Ron, D,&Walter, P.(2007).Signal integration in the endoplasmic reticulum unfolded protein response.NATURE REVIEWS MOLECULAR CELL BIOLOGY,8(7),519-529.
MLA Ron, D,et al."Signal integration in the endoplasmic reticulum unfolded protein response".NATURE REVIEWS MOLECULAR CELL BIOLOGY 8.7(2007):519-529.
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