XTBG OpenIR  > 文献共享
Microbial Genomics as a guide to drug discovery and structural elucidation: ECO-02301, a novel antifungal agent, as an example
McAlpine, JB; Bachmann, BO; Piraee, M; Tremblay, S; Alarco, AM; Zazopoulos, E; Farnet, CM
2005
Source PublicationJOURNAL OF NATURAL PRODUCTS
ISSN0163-3864
Volume68Issue:4Pages:493-496
AbstractAnalysis of the genome of Streptomyces aizunensis NRRL B-11277 indicated its potential to produce a compound of novel and highly predictable structure. The structure was predicted with sufficient accuracy to allow straightforward detection of the specific metabolite in HPLC profiles of fermentation extracts and hence to guide the isolation. The spectroscopic work was reduced to a confirmation of structure rather than a first principle determination. The compound, ECO-02301 (1), demonstrated potent antifungal activity. This work exemplifies not only the discovery of novel antibiotics from well-characterized organisms but also the utility of genomics as a further tool, complementary to spectroscopy, to enable rapid determination of complex structures.
KeywordBiosynthesis Genes
Language英语
Document Type期刊论文
Identifierhttp://ir.xtbg.org.cn/handle/353005/10253
Collection文献共享
Recommended Citation
GB/T 7714
McAlpine, JB,Bachmann, BO,Piraee, M,et al. Microbial Genomics as a guide to drug discovery and structural elucidation: ECO-02301, a novel antifungal agent, as an example[J]. JOURNAL OF NATURAL PRODUCTS,2005,68(4):493-496.
APA McAlpine, JB.,Bachmann, BO.,Piraee, M.,Tremblay, S.,Alarco, AM.,...&Farnet, CM.(2005).Microbial Genomics as a guide to drug discovery and structural elucidation: ECO-02301, a novel antifungal agent, as an example.JOURNAL OF NATURAL PRODUCTS,68(4),493-496.
MLA McAlpine, JB,et al."Microbial Genomics as a guide to drug discovery and structural elucidation: ECO-02301, a novel antifungal agent, as an example".JOURNAL OF NATURAL PRODUCTS 68.4(2005):493-496.
Files in This Item: Download All
File Name/Size DocType Version Access License
Microbial Genomics a(173KB) 开放获取CC BY-NC-SAView Download
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[McAlpine, JB]'s Articles
[Bachmann, BO]'s Articles
[Piraee, M]'s Articles
Baidu academic
Similar articles in Baidu academic
[McAlpine, JB]'s Articles
[Bachmann, BO]'s Articles
[Piraee, M]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[McAlpine, JB]'s Articles
[Bachmann, BO]'s Articles
[Piraee, M]'s Articles
Terms of Use
No data!
Social Bookmark/Share
File name: Microbial Genomics as a Guide to Drug Discovery and Structural Elucidation.pdf
Format: Adobe PDF
This file does not support browsing at this time
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.