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Marine natural products and related compounds in clinical and advanced preclinical trials
Newman, DJ; Cragg, GM
2004
Source PublicationJOURNAL OF NATURAL PRODUCTS
ISSN0163-3864
Volume67Issue:8Pages:1216-1238
AbstractThe marine environment has proven to be a very rich source of extremely potent compounds that have demonstrated significant activities in antitumor, antiinflammatory, analgesia, immunomodulation, allergy, and anti-viral assays. Although the case can and has been made that the nucleosides such as Ara-A and Ara-C are derived from knowledge gained from investigations of bioactive marine nucleosides, no drug directly from marine sources (whether isolated or by total synthesis) has yet made it to the commercial sector in any disease. However, as shown in this review, there are now significant numbers of very interesting molecules that have come from marine sources, or have been synthesized as a result of knowledge gained from a prototypical compound, that are either in or approaching Phase II/III clinical trials in cancer, analgesia, allergy, and cognitive diseases. A substantial number of other potential agents are following in their wake in preclinical trials in these and in other diseases.
KeywordWhip Pseudopterogorgia-elisabethae Antiproliferative Agent Didemnin Alpha-galactosylceramide Krn7000 Sponge Kirkpatrickia-varialosa Candidatus Endobugula Sertula Potent Cytotoxic Depsipeptide Bee Venom Phospholipase-a2 Practical Total-synthesis Mollusk Elysia-rufescens Vivo Antitumor-activity
Language英语
Document Type期刊论文
Identifierhttp://ir.xtbg.org.cn/handle/353005/10255
Collection文献共享
Recommended Citation
GB/T 7714
Newman, DJ,Cragg, GM. Marine natural products and related compounds in clinical and advanced preclinical trials[J]. JOURNAL OF NATURAL PRODUCTS,2004,67(8):1216-1238.
APA Newman, DJ,&Cragg, GM.(2004).Marine natural products and related compounds in clinical and advanced preclinical trials.JOURNAL OF NATURAL PRODUCTS,67(8),1216-1238.
MLA Newman, DJ,et al."Marine natural products and related compounds in clinical and advanced preclinical trials".JOURNAL OF NATURAL PRODUCTS 67.8(2004):1216-1238.
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