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title: Chemical constituents and antiinflammatory activities of Maqian (Zanthoxylum myriacanthum var. pubescens) bark extracts
author: Zhang, Huan-li;  Gan, Xiao-qing;  Fan, Qing-fei;  Yang, Jing-jing;  Zhang, Ping;  Hu, Hua-bin;  Song, Qi-shi
Issued Date: 2017
Abstract: In this study, 44 compounds in the petroleum ether extract of Maqian (Zanthoxylum myriacanthum var. pubescens) bark, a traditional Dai herbal medicine, were identified by GC-MS. Major components included 3(2H)-benzofuranone, asarinin and (dimethoxymethyl)-3-methoxy-benzene. A total of 18 compounds were isolated from the ethyl acetate extracts of Maqian bark by column chromatography and identified by chemical and spectral analyses. Rhoifoline B, zanthoxyline dimethoxy derivative, N-nortidine, nitidine, decarine are the major alkaloids. Both the petroleum ether and ethyl acetate extracts showed significant inhibition on NO production, which imply anti-inflammatory activity, in lipopolysaccharide-induced RAW 264.7 cells without cell toxicity. Decarine is the major antiinflammatory constituent with NO IC50 values of 48.43 mu M on RAW264.7 cells. The petroleum ether extract, the ethyl acetate extract and decarine showed anti-inflammatory activities through inhibiting TNF-alpha and IL-1 beta production in lipopolysaccharide-stimulated THP-1 cells without cell toxicity too. Decarine showed anti-inflammatory activity on human colon cells by reducing IL-6 and IL-8 production in TNF-alpha+ IL-1 beta-induced Caco-2 cells. These results support the use of Maqian bark as a remedy for enteritis and colitis recorded by Dai medicine in China, and elucidate the major pharmacological compounds in Maqian bark.
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Recommended Citation:
Zhang, Huan-li,Gan, Xiao-qing,Fan, Qing-fei,et al. Chemical Constituents And Antiinflammatory Activities Of Maqian (zanthoxylum Myriacanthum Var. Pubescens) Bark Extracts[J]. Scientific Reports,2017,7(X):45805.

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