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Chemical constituents and antiinflammatory activities of Maqian (Zanthoxylum myriacanthum var. pubescens) bark extracts
Zhang, Huan-li; Gan, Xiao-qing; Fan, Qing-fei; Yang, Jing-jing; Zhang, Ping; Hu, Hua-bin; Song, Qi-shi
2017
Source PublicationSCIENTIFIC REPORTS
Volume7Issue:xPages:45805
AbstractIn this study, 44 compounds in the petroleum ether extract of Maqian (Zanthoxylum myriacanthum var. pubescens) bark, a traditional Dai herbal medicine, were identified by GC-MS. Major components included 3(2H)-benzofuranone, asarinin and (dimethoxymethyl)-3-methoxy-benzene. A total of 18 compounds were isolated from the ethyl acetate extracts of Maqian bark by column chromatography and identified by chemical and spectral analyses. Rhoifoline B, zanthoxyline dimethoxy derivative, N-nortidine, nitidine, decarine are the major alkaloids. Both the petroleum ether and ethyl acetate extracts showed significant inhibition on NO production, which imply anti-inflammatory activity, in lipopolysaccharide-induced RAW 264.7 cells without cell toxicity. Decarine is the major antiinflammatory constituent with NO IC50 values of 48.43 mu M on RAW264.7 cells. The petroleum ether extract, the ethyl acetate extract and decarine showed anti-inflammatory activities through inhibiting TNF-alpha and IL-1 beta production in lipopolysaccharide-stimulated THP-1 cells without cell toxicity too. Decarine showed anti-inflammatory activity on human colon cells by reducing IL-6 and IL-8 production in TNF-alpha IL-1 beta-induced Caco-2 cells. These results support the use of Maqian bark as a remedy for enteritis and colitis recorded by Dai medicine in China, and elucidate the major pharmacological compounds in Maqian bark.
KeywordKappa-b Pathway In-vitro Raw264.7 Macrophages Stem Bark C-13 Nmr Cells Xishuangbanna Flavonoids Alkaloids Ether
Language英语
Document Type期刊论文
Identifierhttp://ir.xtbg.org.cn/handle/353005/10341
Collection民族植物学研究组
Recommended Citation
GB/T 7714
Zhang, Huan-li,Gan, Xiao-qing,Fan, Qing-fei,et al. Chemical constituents and antiinflammatory activities of Maqian (Zanthoxylum myriacanthum var. pubescens) bark extracts[J]. SCIENTIFIC REPORTS,2017,7(x):45805.
APA Zhang, Huan-li.,Gan, Xiao-qing.,Fan, Qing-fei.,Yang, Jing-jing.,Zhang, Ping.,...&Song, Qi-shi.(2017).Chemical constituents and antiinflammatory activities of Maqian (Zanthoxylum myriacanthum var. pubescens) bark extracts.SCIENTIFIC REPORTS,7(x),45805.
MLA Zhang, Huan-li,et al."Chemical constituents and antiinflammatory activities of Maqian (Zanthoxylum myriacanthum var. pubescens) bark extracts".SCIENTIFIC REPORTS 7.x(2017):45805.
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