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Cytotoxicity and Synergistic Effect of the Constituents from Roots of Aglaia odorata (Meliaceae)
Liu, Bing; Xu, You-Kai
2016
Source PublicationNATURAL PRODUCT RESEARCH
ISSN1478-6419
Volume30Issue:4Pages:433-437
AbstractTwelve compounds were isolated from the roots of Aglaia odorata. Their structures were established on the basis of NMR and MS data as rocaglaol (1), rocaglamide (2), eichlerialactone (3), sapelins A (4), isofouquierone (5), eichlerianic acid (6), shoreic acid (7), agladupol E (8), 3-epimeliantriol (9), cleomiscosins B (10), 2 beta,3 beta-dihydroxy-5 alpha-pregnane-16-one (11) and beta-D-glucopyranos-1-yl N-methylpyrrole-2-carboxylate (12). Among them, compounds 1 and 2 showed significant cytotoxicity against human cancer cell (HL-60, SMMC-7721, A-549, MCF-7 and SW480) with IC50 values of 0.007-0.095 mu M, while compounds 3-5 and 10 and 11 showed moderate to no cytotoxicity (IC50 0.43 to values >40 mu M). Compound 6 showed only weak cytotoxicity (IC50 6.87 to >40 mu M) and its epmier 7 was completely inactivite (IC50 >40 mu M) in the assay. However, potent synergistic effect was observed when the molar ratio of 6 to 7 is between 4: 1 and 1:1.
Subject AreaChemistry ; Pharmacology & Pharmacy
Language英语
Document Type期刊论文
Identifierhttp://ir.xtbg.org.cn/handle/353005/10441
Collection民族植物学研究组
Corresponding AuthorXu, You-Kai
Recommended Citation
GB/T 7714
Liu, Bing,Xu, You-Kai. Cytotoxicity and Synergistic Effect of the Constituents from Roots of Aglaia odorata (Meliaceae)[J]. NATURAL PRODUCT RESEARCH,2016,30(4):433-437.
APA Liu, Bing,&Xu, You-Kai.(2016).Cytotoxicity and Synergistic Effect of the Constituents from Roots of Aglaia odorata (Meliaceae).NATURAL PRODUCT RESEARCH,30(4),433-437.
MLA Liu, Bing,et al."Cytotoxicity and Synergistic Effect of the Constituents from Roots of Aglaia odorata (Meliaceae)".NATURAL PRODUCT RESEARCH 30.4(2016):433-437.
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