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title: Cytotoxicity and Synergistic Effect of the Constituents from Roots of Aglaia odorata (Meliaceae)
author: Liu, Bing;  Xu, You-Kai
Issued Date: 2016
Abstract: Twelve compounds were isolated from the roots of Aglaia odorata. Their structures were established on the basis of NMR and MS data as rocaglaol (1), rocaglamide (2), eichlerialactone (3), sapelins A (4), isofouquierone (5), eichlerianic acid (6), shoreic acid (7), agladupol E (8), 3-epimeliantriol (9), cleomiscosins B (10), 2 beta,3 beta-dihydroxy-5 alpha-pregnane-16-one (11) and beta-D-glucopyranos-1-yl N-methylpyrrole-2-carboxylate (12). Among them, compounds 1 and 2 showed significant cytotoxicity against human cancer cell (HL-60, SMMC-7721, A-549, MCF-7 and SW480) with IC50 values of 0.007-0.095 mu M, while compounds 3-5 and 10 and 11 showed moderate to no cytotoxicity (IC50 0.43 to values >40 mu M). Compound 6 showed only weak cytotoxicity (IC50 6.87 to >40 mu M) and its epmier 7 was completely inactivite (IC50 >40 mu M) in the assay. However, potent synergistic effect was observed when the molar ratio of 6 to 7 is between 4: 1 and 1:1.
Source: NATURAL PRODUCT RESEARCH
Related URLs: 10.1080/14786419.2015.1016940
Appears in Collections:民族植物学研究组_期刊论文

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Recommended Citation:
Liu, Bing,Xu, You-Kai. Cytotoxicity And Synergistic Effect Of The Constituents From Roots Of Aglaia Odorata (meliaceae)[J]. Natural Product Research,2016,30(4):433-437.

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