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title: New prenylated coumarins from the stems of Toddalia asiatica
author: Li, Wei;  Zhang, Jun-Sheng;  Huang, Jia-Luo;  Jiang, Min-Hong;  Xu, You-Kai;  Ahmed, Abrar;  Yin, Sheng;  Tang, Gui-Hua
Issued Date: 2017
Abstract: Eight new prenylated coumarins (1a/1b, 2a/2b, and 3-6) including two pairs of enantiomers (1a/1b and 2a/2b), a new phenolic acid derivative, methyl (E)-3,4-bis(4-hydroxyphenyl)-4-oxobut-2-enoate (7), and 33 known compounds (8-40) were isolated from the stems of Toddalia asiatica. Their structures were established from spectroscopic data and by chemical methods. The absolute configurations of two pairs of enantiomers (1a/1b and 2a/2b) were determined by X-ray diffraction analysis together with ECD and specific optical rotation calculations. The inhibitory effects of selected compounds against phosphodiesterase-4 (PDE4) were evaluated, and compounds 12, 19, 21-23, 26, 34, and 35 exhibited PDE4 inhibition activities with IC50 values less than 10 mu M.
Related URLs: 10.1039/c7ra04794k
Appears in Collections:民族植物学研究组_期刊论文

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Recommended Citation:
Li, Wei,Zhang, Jun-Sheng,Huang, Jia-Luo,et al. New Prenylated Coumarins From The Stems Of Toddalia Asiatica[J]. Rsc Advances,2017,7(49):31061-31068.

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