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New prenylated coumarins from the stems of Toddalia asiatica
Li, Wei; Zhang, Jun-Sheng; Huang, Jia-Luo; Jiang, Min-Hong; Xu, You-Kai; Ahmed, Abrar; Yin, Sheng; Tang, Gui-Hua
2017
Source PublicationRSC ADVANCES
Volume7Issue:49Pages:31061-31068
AbstractEight new prenylated coumarins (1a/1b, 2a/2b, and 3-6) including two pairs of enantiomers (1a/1b and 2a/2b), a new phenolic acid derivative, methyl (E)-3,4-bis(4-hydroxyphenyl)-4-oxobut-2-enoate (7), and 33 known compounds (8-40) were isolated from the stems of Toddalia asiatica. Their structures were established from spectroscopic data and by chemical methods. The absolute configurations of two pairs of enantiomers (1a/1b and 2a/2b) were determined by X-ray diffraction analysis together with ECD and specific optical rotation calculations. The inhibitory effects of selected compounds against phosphodiesterase-4 (PDE4) were evaluated, and compounds 12, 19, 21-23, 26, 34, and 35 exhibited PDE4 inhibition activities with IC50 values less than 10 mu M.
Department其他
Language英语
Document Type期刊论文
Identifierhttp://ir.xtbg.org.cn/handle/353005/10783
Collection民族植物学研究组
Recommended Citation
GB/T 7714
Li, Wei,Zhang, Jun-Sheng,Huang, Jia-Luo,et al. New prenylated coumarins from the stems of Toddalia asiatica[J]. RSC ADVANCES,2017,7(49):31061-31068.
APA Li, Wei.,Zhang, Jun-Sheng.,Huang, Jia-Luo.,Jiang, Min-Hong.,Xu, You-Kai.,...&Tang, Gui-Hua.(2017).New prenylated coumarins from the stems of Toddalia asiatica.RSC ADVANCES,7(49),31061-31068.
MLA Li, Wei,et al."New prenylated coumarins from the stems of Toddalia asiatica".RSC ADVANCES 7.49(2017):31061-31068.
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