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Oryza sativa POSITIVE REGULATOR OF IRON DEFICIENCY RESPONSE 2 (OsPRI2) and OsPRI3 are involved in the maintenance of Fe homeostasis
Zhang, Huimin; Li, Yang; Pu, Mengna; Xu, Peng; Liang, Gang; Yu, Diqiu
2020
Source PublicationPLANT CELL AND ENVIRONMENT
ISSN0140-7791
IssuexPages:-
Abstract

Iron (Fe) is an essential micronutrient for plant growth development and plays a key role in regulating numerous cellular processes. In rice, OsHRZ1, an Fe-binding ubiquitin ligase, is a putative sensor of Fe homeostasis that negatively regulates iron acquisition. Despite its apparent importance, only a single basic-Helix-Loop-Helix (bHLH) transcription factor, OsPRI1, has been identified as a direct target of OsHRZ1. In this study, we identified and functionally characterized OsPRI2 and OsPRI3, two paralogs of OsPRI1, observing that they directly interact with OsHRZ1. Additional analyses suggested that OsHRZ1 promotes the degradation of OsPRI2 and OsPRI3. The translocation of Fe from roots to shoots was impaired in plants with loss-of-function mutations in OsPRI2 or OsPRI3, causing the downregulation of Fe-deficiency-responsive genes. In contrast, overexpression of OsPRI2 and OsPRI3 promotes Fe accumulation and activates the expression of Fe-deficiency-responsive genes. We also provide evidence that OsPRI2 and OsPRI3 bind to the promoters of OsIRO2 and OsIRO3, two key regulators of Fe homeostasis. Moreover, OsPRI2 and OsPRI3 directly induce expression of the metal-nicotianamine transporter, OsYSL2, by associating with the promoter in response to Fe deficiency. Our results provide insights into the complex network regulating Fe homeostasis in rice.

Keywordiron OsHRZ1 OsIRO2 OsIRO3 OsYSL2 rice
Subject AreaPlant Sciences
DOI10.1111/pce.13655
Indexed BySCI
Language英语
WOS IDWOS:000495759100001
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Document Type期刊论文
Identifierhttp://ir.xtbg.org.cn/handle/353005/11502
Collection植物分子生物学研究组
AffiliationChinese Acad Sci, Innovat Acad Seed Design, CAS Key Lab Trop Plant Resources & Sustainable Us, Xishuangbanna Trop Bot Garden, Kunming 650223, Yunnan, Peoples R China
Recommended Citation
GB/T 7714
Zhang, Huimin,Li, Yang,Pu, Mengna,et al. Oryza sativa POSITIVE REGULATOR OF IRON DEFICIENCY RESPONSE 2 (OsPRI2) and OsPRI3 are involved in the maintenance of Fe homeostasis[J]. PLANT CELL AND ENVIRONMENT,2020(x):-.
APA Zhang, Huimin,Li, Yang,Pu, Mengna,Xu, Peng,Liang, Gang,&Yu, Diqiu.(2020).Oryza sativa POSITIVE REGULATOR OF IRON DEFICIENCY RESPONSE 2 (OsPRI2) and OsPRI3 are involved in the maintenance of Fe homeostasis.PLANT CELL AND ENVIRONMENT(x),-.
MLA Zhang, Huimin,et al."Oryza sativa POSITIVE REGULATOR OF IRON DEFICIENCY RESPONSE 2 (OsPRI2) and OsPRI3 are involved in the maintenance of Fe homeostasis".PLANT CELL AND ENVIRONMENT .x(2020):-.
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