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IRON MAN interacts with BRUTUS to maintain iron homeostasis in Arabidopsis
Li, Yang1; Lu, Cheng Kai1; Li, Chen Yang1,2; Lei, Ri Hua1; Pu, Meng Na1,2; Zhao, Jun Hui1,2; Peng, Feng1,2; Ping, Hua Qian1,2; Wang, Dan1,2; Liang, Gang1,2
2021
Source PublicationPROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
ISSN0027-8424
Volume118Issue:39Pages:-
AbstractIRON MAN (IMA) peptides, a family of small peptides, control iron (Fe) transport in plants, but their roles in Fe signaling remain unclear. BRUTUS (BTS) is a potential Fe sensor that negatively regulates Fe homeostasis by promoting the ubiquitin-mediated degradation of bHLH105 and bHLH115, two positive regulators of the Fe deficiency response. Here, we show that IMA peptides interact with BTS. The C-terminal parts of IMA peptides contain a conserved BTS interaction domain (BID) that is responsible for their interaction with the C terminus of BTS. Arabidopsis thaliana plants constitutively expressing IMA genes phenocopy the bts-2 mutant. Moreover, IMA peptides are ubiquitinated and degraded by BTS. bHLH105 and bHLH115 also share a BID, which accounts for their interaction with BTS. IMA peptides compete with bHLH105/bHLH115 for interaction with BTS, thereby inhibiting the degradation of these transcription factors by BTS. Genetic analyses suggest that bHLH105/bHLH115 and IMA3 have additive roles and function downstream of BTS. Moreover, the transcription of both BTS and IMA3 is activated directly by bHLH105 and bHLH115 under Fe-deficient conditions. Our findings provide a conceptual framework for understanding the regulation of Fe homeostasis: IMA peptides protect bHLH105/bHLH115 from degradation by sequestering BTS, thereby activating the Fe deficiency response.
Keywordiron BTS bHLH105 bHLH115 IMA
Subject AreaScience & Technology - Other Topics
DOI10.1073/pnas.2109063118
Indexed BySCI
Language英语
WOS IDWOS:000705916200007
Citation statistics
Document Type期刊论文
Identifierhttp://ir.xtbg.org.cn/handle/353005/12394
Collection2012年后新成立研究组
Affiliation1.Chinese Acad Sci, Innovat Acad Seed Design, Xishuangbanna Trop Bot Garden, CAS Key Lab Trop Plant Resources & Sustainable Us, Kunming 650223, Yunnan, Peoples R China
2.Chinese Acad Sci, Core Bot Gardens, Ctr Econ Bot, Mengla 666303, Peoples R China
3.Univ Chinese Acad Sci, Coll Life Sci, Beijing 100049, Peoples R China
Recommended Citation
GB/T 7714
Li, Yang,Lu, Cheng Kai,Li, Chen Yang,et al. IRON MAN interacts with BRUTUS to maintain iron homeostasis in Arabidopsis[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,2021,118(39):-.
APA Li, Yang.,Lu, Cheng Kai.,Li, Chen Yang.,Lei, Ri Hua.,Pu, Meng Na.,...&Liang, Gang.(2021).IRON MAN interacts with BRUTUS to maintain iron homeostasis in Arabidopsis.PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,118(39),-.
MLA Li, Yang,et al."IRON MAN interacts with BRUTUS to maintain iron homeostasis in Arabidopsis".PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 118.39(2021):-.
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