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title: Koumine, Humantenine, and Yohimbane Alkaloids from Gelsemium elegans
author: You-Kai Xu;  Lin Yang;  Shang-Gao Liao;  Pei Cao;  Bin Wu;  Hua-Bin Hu;  Juan Guo;  Ping Zhang
Issued Date: 2015
Abstract: Nine new alkaloids of the koumine (14), humantenine (57), and yohimbane (89) types as well as 12 known analogues were isolated from the leaves and vine stems of Gelsemium elegans. Compound 1 is the first N-4-demethyl alkaloid of the koumine type, compound 7 is the first nor-humantenine alkaloid, and compounds 8 and 9 are the first N-1-oxide and the firstseco-E-ring alkaloids, respectively, of the yohimbane type. Compounds 1 and 7 exhibited moderate cytotoxicity against five human tumor cell lines with IC50 values in the range 4.6–9.3 μM.
Source: Journal of Natural Products
Appears in Collections:民族植物学研究组_期刊论文

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Recommended Citation:
You-Kai Xu,Lin Yang,Shang-Gao Liao,et al. Koumine, Humantenine, And Yohimbane Alkaloids From Gelsemium Elegans[J]. Journal Of Natural Products,2015,78(7):1511-1517.

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