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Cytotoxic limonoids from Trichilia americana leaves
Ji, Kai-Long; Zhang, Ping; Li, Xiao-Nian; Guo, Juan; Hu, Hua-Bin; Xiao, Chun-Fen; Xie, Xiang-Qun; Xu, You-Kai
2015
Source PublicationPHYTOCHEMISTRY
ISSN0031-9422
Volume118Pages:61-67
AbstractTen cedrelone limonoids were isolated from the leaves of Trichilia americana. These compounds include americanolides A-D (1-4), 1,2-dihydrodeacetylhirtin (5), 1 alpha-hydroxy-1,2-dihydrodeacetylhirtin (6), 1ahydroxy-1,2-dihydrohirtin (7), 1 alpha-methoxy-1,2-dihydrodeacetylhirtin (8), 11 beta-hydroxy-12 alpha-propanoyloxycedrelone (9), and 1 alpha,11 beta-dihydroxy-1,2-dihydrocedrelone (10), as well as two previously reported compounds, deacetylhirtin (11) and hirtin (12). Their structures were characterized on the basis of spectroscopic studies, and the assignment of the absolute configuration of americanolide A (1) was supported by single-crystal X-ray diffraction studies. The cytotoxic activities of all isolated compounds were also evaluated against five human tumour cell lines (HL-60, SMMC-7721, A-549, MCF-7, and SW-480) using an MTS assay. Compounds 11 and 12 showed significant cytotoxicity with IC50 values ranging from 0.1 to 0.5 mu M, and compounds 5, 6, 7, 8, 9, and 10 exhibited potent or selective cytotoxic activity with IC50 values ranging from 1.0 to 39.6 mu M. (C) 2015 Elsevier Ltd. All rights reserved.
KeywordTrichilia Americana Meliaceae Cedrelone Limonoids Cytotoxicity
Funding Organization135 Programs of Xishuangbanna Tropical Botanical Garden; Chinese Academy of Sciences [XTBG-F02]; Yunnan Province; National Natural Science Union Foundation of China [NSFC-U1302222]; Ethnobotanical Investigation of Plants for Industrialization in Southwest China [SQ2012FY4910027]
Language英语
Document Type期刊论文
Identifierhttp://ir.xtbg.org.cn/handle/353005/9350
Collection民族植物学研究组
Recommended Citation
GB/T 7714
Ji, Kai-Long,Zhang, Ping,Li, Xiao-Nian,et al. Cytotoxic limonoids from Trichilia americana leaves[J]. PHYTOCHEMISTRY,2015,118:61-67.
APA Ji, Kai-Long.,Zhang, Ping.,Li, Xiao-Nian.,Guo, Juan.,Hu, Hua-Bin.,...&Xu, You-Kai.(2015).Cytotoxic limonoids from Trichilia americana leaves.PHYTOCHEMISTRY,118,61-67.
MLA Ji, Kai-Long,et al."Cytotoxic limonoids from Trichilia americana leaves".PHYTOCHEMISTRY 118(2015):61-67.
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