XTBG OpenIR  > 民族植物学研究组
Cytotoxic limonoids from Trichilia americana leaves
Ji, Kai-Long; Zhang, Ping; Li, Xiao-Nian; Guo, Juan; Hu, Hua-Bin; Xiao, Chun-Fen; Xie, Xiang-Qun; Xu, You-Kai
Source PublicationPHYTOCHEMISTRY
AbstractTen cedrelone limonoids were isolated from the leaves of Trichilia americana. These compounds include americanolides A-D (1-4), 1,2-dihydrodeacetylhirtin (5), 1 alpha-hydroxy-1,2-dihydrodeacetylhirtin (6), 1ahydroxy-1,2-dihydrohirtin (7), 1 alpha-methoxy-1,2-dihydrodeacetylhirtin (8), 11 beta-hydroxy-12 alpha-propanoyloxycedrelone (9), and 1 alpha,11 beta-dihydroxy-1,2-dihydrocedrelone (10), as well as two previously reported compounds, deacetylhirtin (11) and hirtin (12). Their structures were characterized on the basis of spectroscopic studies, and the assignment of the absolute configuration of americanolide A (1) was supported by single-crystal X-ray diffraction studies. The cytotoxic activities of all isolated compounds were also evaluated against five human tumour cell lines (HL-60, SMMC-7721, A-549, MCF-7, and SW-480) using an MTS assay. Compounds 11 and 12 showed significant cytotoxicity with IC50 values ranging from 0.1 to 0.5 mu M, and compounds 5, 6, 7, 8, 9, and 10 exhibited potent or selective cytotoxic activity with IC50 values ranging from 1.0 to 39.6 mu M. (C) 2015 Elsevier Ltd. All rights reserved.
KeywordTrichilia Americana Meliaceae Cedrelone Limonoids Cytotoxicity
Funding Organization135 Programs of Xishuangbanna Tropical Botanical Garden; Chinese Academy of Sciences [XTBG-F02]; Yunnan Province; National Natural Science Union Foundation of China [NSFC-U1302222]; Ethnobotanical Investigation of Plants for Industrialization in Southwest China [SQ2012FY4910027]
Document Type期刊论文
Recommended Citation
GB/T 7714
Ji, Kai-Long,Zhang, Ping,Li, Xiao-Nian,et al. Cytotoxic limonoids from Trichilia americana leaves[J]. PHYTOCHEMISTRY,2015,118:61-67.
APA Ji, Kai-Long.,Zhang, Ping.,Li, Xiao-Nian.,Guo, Juan.,Hu, Hua-Bin.,...&Xu, You-Kai.(2015).Cytotoxic limonoids from Trichilia americana leaves.PHYTOCHEMISTRY,118,61-67.
MLA Ji, Kai-Long,et al."Cytotoxic limonoids from Trichilia americana leaves".PHYTOCHEMISTRY 118(2015):61-67.
Files in This Item: Download All
File Name/Size DocType Version Access License
Cytotoxic limonoids (808KB) 开放获取CC BY-NC-SAView Download
Related Services
Recommend this item
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Ji, Kai-Long]'s Articles
[Zhang, Ping]'s Articles
[Li, Xiao-Nian]'s Articles
Baidu academic
Similar articles in Baidu academic
[Ji, Kai-Long]'s Articles
[Zhang, Ping]'s Articles
[Li, Xiao-Nian]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Ji, Kai-Long]'s Articles
[Zhang, Ping]'s Articles
[Li, Xiao-Nian]'s Articles
Terms of Use
No data!
Social Bookmark/Share
File name: Cytotoxic limonoids from Trichilia americana leaves.pdf
Format: Adobe PDF
This file does not support browsing at this time
All comments (0)
No comment.

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.