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title: Phytosteroids and triterpenoids with potent cytotoxicities from the leaves of Chisocheton cumingianus
author: Huang, Shan-Shan;  Jian, Kai-Li;  Li, Rui-Jun;  Kong, Ling-Yi;  Yang, Ming-Hua
Issued Date: 2016
Abstract: Six phytosteroids and three dammarane-type triterpenoids, namely chisopanoids A-F (1-6) and chisopanones G-I (7-9), together with nine known triterpenoids (10-18) were isolated from the leaves of Chisocheton cumingianus. Their structures were elucidated by extensive spectroscopic analysis, X-ray crystallographic analysis, Mosher's method and Mo-2(OAc)(4)-induced electronic circular dichroism (ECD) data. All compounds were evaluated for their cytotoxicities against HepG2, U2OS and MCF-7 human cancer cell lines, as well as inhibitory effects on nitric oxide (NO) production in LPS-activated RAW 264.7 macrophages. Compounds 5 and 6 showed potent cytotoxicities towards MCF-7 with IC50 values of 3.24 +/- 1.39 and 8.85 +/- 4.73 mu M, and were further proved to inhibit the cell proliferation mainly by inducing apoptosis.
Source: RSC ADVANCES
Related URLs: 10.1039/c5ra23626f
Appears in Collections:文献共享_期刊论文

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Recommended Citation:
Huang, Shan-Shan,Jian, Kai-Li,Li, Rui-Jun,et al. Phytosteroids And Triterpenoids With Potent Cytotoxicities From The Leaves Of Chisocheton Cumingianus[J]. Rsc Advances,2016,6(8):6320-6328.

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