Advanced   Register
XTBG OpenIR  > 文献共享  > 期刊论文

title: Phytosteroids and triterpenoids with potent cytotoxicities from the leaves of Chisocheton cumingianus
author: Huang, Shan-Shan;  Jian, Kai-Li;  Li, Rui-Jun;  Kong, Ling-Yi;  Yang, Ming-Hua
Issued Date: 2016
Abstract: Six phytosteroids and three dammarane-type triterpenoids, namely chisopanoids A-F (1-6) and chisopanones G-I (7-9), together with nine known triterpenoids (10-18) were isolated from the leaves of Chisocheton cumingianus. Their structures were elucidated by extensive spectroscopic analysis, X-ray crystallographic analysis, Mosher's method and Mo-2(OAc)(4)-induced electronic circular dichroism (ECD) data. All compounds were evaluated for their cytotoxicities against HepG2, U2OS and MCF-7 human cancer cell lines, as well as inhibitory effects on nitric oxide (NO) production in LPS-activated RAW 264.7 macrophages. Compounds 5 and 6 showed potent cytotoxicities towards MCF-7 with IC50 values of 3.24 +/- 1.39 and 8.85 +/- 4.73 mu M, and were further proved to inhibit the cell proliferation mainly by inducing apoptosis.
Related URLs: 10.1039/c5ra23626f
Appears in Collections:文献共享_期刊论文

Files in This Item:

File SizeFormat
Phytosteroids and triterpenoids with potent cytotoxicities from the leaves of Chisocheton cumingianus .pdf670KbAdobe PDFView  联系获取全文

全文许可: Creative Commons 署名-非商业性使用-相同方式共享 3.0

Recommended Citation:
Huang, Shan-Shan,Jian, Kai-Li,Li, Rui-Jun,et al. Phytosteroids And Triterpenoids With Potent Cytotoxicities From The Leaves Of Chisocheton Cumingianus[J]. Rsc Advances,2016,6(8):6320-6328.

SCI Citaion Data:
 Recommend this item
 Sava as my favorate item
 Show this item's statistics
 Export Endnote File
Google Scholar
 Similar articles in Google Scholar
 [Huang, Shan-Shan]'s Articles
 [Jian, Kai-Li]'s Articles
 [Li, Rui-Jun]'s Articles
CSDL cross search
 Similar articles in CSDL Cross Search
 [Huang, Shan-Shan]‘s Articles
 [Jian, Kai-Li]‘s Articles
 [Li, Rui-Jun]‘s Articles
Scirus search
 Similar articles in Scirus
Related Copyright Policies
Social Bookmarking
  Add to CiteULike  Add to Connotea  Add to  Add to Digg  Add to Reddit 
所有评论 (0)
内 容:
Email:  *
验证码:   刷新
标 题:
内 容:
Email:  *
验证码:   刷新

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.



Valid XHTML 1.0!
Powered by CSpace