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Phytosteroids and triterpenoids with potent cytotoxicities from the leaves of Chisocheton cumingianus
Huang, Shan-Shan; Jian, Kai-Li; Li, Rui-Jun; Kong, Ling-Yi; Yang, Ming-Hua
2016
Source PublicationRSC ADVANCES
ISSN2046-2069
Volume6Issue:8Pages:6320-6328
AbstractSix phytosteroids and three dammarane-type triterpenoids, namely chisopanoids A-F (1-6) and chisopanones G-I (7-9), together with nine known triterpenoids (10-18) were isolated from the leaves of Chisocheton cumingianus. Their structures were elucidated by extensive spectroscopic analysis, X-ray crystallographic analysis, Mosher's method and Mo-2(OAc)(4)-induced electronic circular dichroism (ECD) data. All compounds were evaluated for their cytotoxicities against HepG2, U2OS and MCF-7 human cancer cell lines, as well as inhibitory effects on nitric oxide (NO) production in LPS-activated RAW 264.7 macrophages. Compounds 5 and 6 showed potent cytotoxicities towards MCF-7 with IC50 values of 3.24 /- 1.39 and 8.85 /- 4.73 mu M, and were further proved to inhibit the cell proliferation mainly by inducing apoptosis.
KeywordAbsolute-configuration Dammarane Triterpenes Oxidation-products Constituents
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Indexed BySCI
Language英语
Document Type期刊论文
Identifierhttp://ir.xtbg.org.cn/handle/353005/9799
Collection文献共享
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GB/T 7714
Huang, Shan-Shan,Jian, Kai-Li,Li, Rui-Jun,et al. Phytosteroids and triterpenoids with potent cytotoxicities from the leaves of Chisocheton cumingianus[J]. RSC ADVANCES,2016,6(8):6320-6328.
APA Huang, Shan-Shan,Jian, Kai-Li,Li, Rui-Jun,Kong, Ling-Yi,&Yang, Ming-Hua.(2016).Phytosteroids and triterpenoids with potent cytotoxicities from the leaves of Chisocheton cumingianus.RSC ADVANCES,6(8),6320-6328.
MLA Huang, Shan-Shan,et al."Phytosteroids and triterpenoids with potent cytotoxicities from the leaves of Chisocheton cumingianus".RSC ADVANCES 6.8(2016):6320-6328.
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