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Target-oriented Mechanisms of Novel Herbal Therapeutics in the Chemotherapy of Gastrointestinal Cancer and Inflammation
Ko, Joshua K.; Auyeung, Kathy K.
2013
Source PublicationCURRENT PHARMACEUTICAL DESIGN
ISSN1381-6128
Volume19Issue:1Pages:48-66
AbstractA prominent group of effective cancer chemopreventive drugs has been derived from natural products having low toxicity while possessing apparent benefit in the disease process. It is plausible that there are multiple target molecules critical to cancer cell survival. Herbal terpenoids have demonstrated excellent target-specific anti-neoplastic functions by suppression of cell proliferation and induction of apoptosis. Transcriptional molecules in the NF-kappa B, MEK/ERK and PI3K/Akt/mTOR pathways are important molecular targets of chemotherapy that play distinctive roles in modulating the apoptosis cascades. It is recently suggested that NSAID-activated gene (NAG-1), a novel proapoptotic protein, is the upstream anti-carcinogenic target of NSAIDs, PPAR ligands and herbal chemotherapeutic agents that triggers some of the events mentioned above. Besides, angiogenesis, oxidative stress as well as inflammation are important factors that contribute to the development and metastasis of cancer, which could be actively modulated by novel agents of plant origin. The aim of the present review is to discuss and summarize the contemporary use of herbal therapeutics and phytochemicals in the treatment of human cancers, in particular that of the colon. The major events and signaling pathways in the carcinogenesis process being potentially modulated by natural products and novel herbal compounds will be evaluated, with emphasis on some terpenoids. Advances in eliciting the precise cellular and molecular mechanisms during the anti-tumorigenic process of novel herbal therapeutics will be of imperative clinical significance to increase the efficacy and reduce prominent adverse drug effects in cancer patients through target-specific therapy.
KeywordNf-kappa-b Human Colon-cancer Activated Gene Nag-1 Hypoxia-inducible Factor Ginger Zingiber-officinale Epidermal-growth-factor Nitric-oxide Synthase Etoposide-induced Apoptosis Early Diabetic-nephropathy Tumor-cell Proliferation
Indexed BySCI
Language英语
Document Type期刊论文
Identifierhttp://ir.xtbg.org.cn/handle/353005/9827
Collection文献共享
Recommended Citation
GB/T 7714
Ko, Joshua K.,Auyeung, Kathy K.. Target-oriented Mechanisms of Novel Herbal Therapeutics in the Chemotherapy of Gastrointestinal Cancer and Inflammation[J]. CURRENT PHARMACEUTICAL DESIGN,2013,19(1):48-66.
APA Ko, Joshua K.,&Auyeung, Kathy K..(2013).Target-oriented Mechanisms of Novel Herbal Therapeutics in the Chemotherapy of Gastrointestinal Cancer and Inflammation.CURRENT PHARMACEUTICAL DESIGN,19(1),48-66.
MLA Ko, Joshua K.,et al."Target-oriented Mechanisms of Novel Herbal Therapeutics in the Chemotherapy of Gastrointestinal Cancer and Inflammation".CURRENT PHARMACEUTICAL DESIGN 19.1(2013):48-66.
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