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title: Trigohowilols A-G, Degraded Diterpenoids from the Stems of Trigonostemon howii
author: Tang, Gui-Hua;  Zhang, Yu;  Yuan, Chun-Mao;  Li, Yan;  Gu, Yu-Cheng;  Di, Ying-Tong;  Wang, Yue-Hu;  Zuo, Guo-Ying;  Li, Shi-Fei;  Li, Shun-Lin;  He, Hong-Ping;  Hao, Xiao-Jiang
Issued Date: 2012
Abstract: Two new degraded diterpenoids, trigohowilols A (1) and B (2), four new heterodimers, trigohowilols C-F (3-6), one new homodimer, trigohowilol G (7), and three known degraded diterpenoids (8-10) were isolated from the methanol extract of the stems of Trigonostemon howii. Compounds 1-7 were evaluated for their cytotoxic activity against five human tumor cell lines by an MTT assay, and trigohowilols E (5) and F (6) exhibited inhibitory activity with IC50 values ranging from 2.33 to 12.57 mu M Moreover, compounds 1-6 showed weak antimicrobial activities (MIC values: 6.25-25 mu g/mL) against Staphylococcus aureus, Pseudomonas aeruginosa, MRSA 92(#), and MRSA 98(#) using a 2-fold dilution method.
Related URLs: 10.1021/np3006315
Appears in Collections:文献共享_期刊论文

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Recommended Citation:
Tang, Gui-Hua,Zhang, Yu,Yuan, Chun-Mao,et al. Trigohowilols A-g, Degraded Diterpenoids From The Stems Of Trigonostemon Howii[J]. Journal Of Natural Products,2012,75(11):1962-1966.

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