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Trigohowilols A-G, Degraded Diterpenoids from the Stems of Trigonostemon howii
Tang, Gui-Hua; Zhang, Yu; Yuan, Chun-Mao; Li, Yan; Gu, Yu-Cheng; Di, Ying-Tong; Wang, Yue-Hu; Zuo, Guo-Ying; Li, Shi-Fei; Li, Shun-Lin; He, Hong-Ping; Hao, Xiao-Jiang
2012
Source PublicationJOURNAL OF NATURAL PRODUCTS
ISSN0163-3864
Volume75Issue:11Pages:1962-1966
AbstractTwo new degraded diterpenoids, trigohowilols A (1) and B (2), four new heterodimers, trigohowilols C-F (3-6), one new homodimer, trigohowilol G (7), and three known degraded diterpenoids (8-10) were isolated from the methanol extract of the stems of Trigonostemon howii. Compounds 1-7 were evaluated for their cytotoxic activity against five human tumor cell lines by an MTT assay, and trigohowilols E (5) and F (6) exhibited inhibitory activity with IC50 values ranging from 2.33 to 12.57 mu M Moreover, compounds 1-6 showed weak antimicrobial activities (MIC values: 6.25-25 mu g/mL) against Staphylococcus aureus, Pseudomonas aeruginosa, MRSA 92(#), and MRSA 98(#) using a 2-fold dilution method.
KeywordDaphnane-type Diterpenoids Chinensis Heterophyllus Reidioides Alkaloids
Indexed BySCI
Language英语
Document Type期刊论文
Identifierhttp://ir.xtbg.org.cn/handle/353005/9828
Collection文献共享
Recommended Citation
GB/T 7714
Tang, Gui-Hua,Zhang, Yu,Yuan, Chun-Mao,et al. Trigohowilols A-G, Degraded Diterpenoids from the Stems of Trigonostemon howii[J]. JOURNAL OF NATURAL PRODUCTS,2012,75(11):1962-1966.
APA Tang, Gui-Hua.,Zhang, Yu.,Yuan, Chun-Mao.,Li, Yan.,Gu, Yu-Cheng.,...&Hao, Xiao-Jiang.(2012).Trigohowilols A-G, Degraded Diterpenoids from the Stems of Trigonostemon howii.JOURNAL OF NATURAL PRODUCTS,75(11),1962-1966.
MLA Tang, Gui-Hua,et al."Trigohowilols A-G, Degraded Diterpenoids from the Stems of Trigonostemon howii".JOURNAL OF NATURAL PRODUCTS 75.11(2012):1962-1966.
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