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Cytotoxicity and Synergistic Effect of the Constituents from Roots of Aglaia odorata (Meliaceae
Bing Liu; You-Kai Xu
2016
Source PublicationNatural Product Research
Volume30Issue:4Pages:433-437
AbstractTwelve compounds were isolated from the roots of Aglaia odorata. Their structures were established on the basis of NMR and MS data as rocaglaol (1), rocaglamide (2), eichlerialactone (3), sapelins A (4), isofouquierone (5), eichlerianic acid (6), shoreic acid (7), agladupol E (8), 3-epimeliantriol (9), cleomiscosins B (10), 2β,3β-dihydroxy-5α-pregnane-16-one (11) and β-d-glucopyranos-1-yl N-methylpyrrole-2-carboxylate (12). Among them, compounds 1 and 2 showed significant cytotoxicity against human cancer cell (HL-60, SMMC-7721, A-549, MCF-7 and SW480) with IC50 values of 0.007–0.095 μM, while compounds 35 and 10 and 11 showed moderate to no cytotoxicity (IC50 0.43 to values >40 μM). Compound 6 showed only weak cytotoxicity (IC50 6.87 to >40 μM) and its epmier7 was completely inactivite (IC50>40 μM) in the assay. However, potent synergistic effect was observed when the molar ratio of 6 to 7 is between 4:1 and 1:1.
Document Type期刊论文
Identifierhttp://ir.xtbg.org.cn/handle/353005/9887
Collection民族植物学研究组
Recommended Citation
GB/T 7714
Bing Liu,You-Kai Xu. Cytotoxicity and Synergistic Effect of the Constituents from Roots of Aglaia odorata (Meliaceae[J]. Natural Product Research,2016,30(4):433-437.
APA Bing Liu,&You-Kai Xu.(2016).Cytotoxicity and Synergistic Effect of the Constituents from Roots of Aglaia odorata (Meliaceae.Natural Product Research,30(4),433-437.
MLA Bing Liu,et al."Cytotoxicity and Synergistic Effect of the Constituents from Roots of Aglaia odorata (Meliaceae".Natural Product Research 30.4(2016):433-437.
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